Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex on Guam: Immunohistochemical Studies.
نویسندگان
چکیده
منابع مشابه
Amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam: immunohistochemical studies.
The incidence of amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) among the Chamorros in Guam is remarkably high. The patients with ALS have clinical and pathological characteristics similar to those in other parts of the world. The PDC patients display parkinsonism and progressive dementia and show a characteristic neuronal loss in certain parts of the central nervou...
متن کاملC9orf72 hexanucleotide repeat expansion and Guam amyotrophic lateral sclerosis-Parkinsonism-dementia complex.
IMPORTANCE High-prevalence foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) exist in Japanese on the Kii Peninsula of Japan and in the Chamorros of Guam. Clinical and neuropathologic similarities suggest that the disease in these 2 populations may be related. Recent findings showed that some of the Kii Peninsula ALS cases had pathogenic C9orf72 repeat expansio...
متن کاملAmyotrophic lateral sclerosis, Parkinson's disease, and the amyotrophic lateral sclerosis-Parkinsonism-dementia complex on Guam: a review and summary of attempts to demonstrate infection as the aetiology.
In a series of lectures delivered in 1874, Charcot described a new syndrome which he termed amyo-trophlc lateral sclerosis (ALS). At that time he presented the essential pathological and classical characteristics of the disease which, although later modified and refined by himself and subsequent workers, have remained remarkedly classical for ALS during the almost 100 years since they were publ...
متن کاملAmyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years.
In the 1950s, the incidence of amyotrophic lateral sclerosis (ALS, or Lytico) and parkinsonism-dementia complex (PDC, or Bodig) on the island of Guam was much higher than anywhere else in the world. From the late 1960s to the early 1980s, the incidence of both disorders has decreased. The objective of the present study was to ascertain whether the decreasing incidence continued until the end of...
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Copyright: © 2017 Kokubo Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 1992
ISSN: 1880-1293,0022-9717
DOI: 10.2302/kjm.41.6